L-(+)-Ergothioneine CAS 497-30-3 THIONEINE Dietary supplement white powder cosmetics raw material

Description

L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.

Basic Parameters:

Chemical Formula:

Overview:

Ergothioneine is an amino acid that is found mainly in mushrooms, as well as red and black beans. It is also found in animals that have eaten grasses containing ergothioneine. Ergothioneine is sometimes used as medicine.

People use ergothioneine for joint pain, liver damage, cataracts, Alzheimer disease, diabetes, heart disease, wrinkles, and other conditions, but there is no good scientific evidence to support these uses.

What is the action of ergothioneine antioxidant?

Ergothioneine is a powerful scavenger of hypochlorous acid, being able to protect alpha 1-antiproteinase against inactivation by this molecule. By contrast, it does not react rapidly with superoxide (O2-) or hydrogen peroxide (H2O2) and it does not inhibit microsomal lipid peroxidation in the presence of iron ions.

Where is ergothioneine found in body?

In the human body, the largest amounts of ergothioneine are found in erythrocytes, eye lens, semen, and skin. Although many species contain ergothioneine, only a few make it; the others absorb it from their diet or, in the case of plants, from their environment.

What is the role of antioxidants in reducing inflammation?

Antioxidants protects tissues from damage against reactive oxygen species and other free radicals. Because antioxidants protect tissues from damage, they prevent unwanted inflammatory responses occurring in the first place.

What is the action of ergothioneine antioxidant?

Ergothioneine is a powerful scavenger of hypochlorous acid, being able to protect alpha 1-antiproteinase against inactivation by this molecule. By contrast, it does not react rapidly with superoxide (O2-) or hydrogen peroxide (H2O2) and it does not inhibit microsomal lipid peroxidation in the presence of iron ions.

Is ergothioneine safe for skin?

Researches suggests that ergothioneine is not harmful to your skin because it occurs; naturally, so it is not likely to cause any irritation when applied topically to your skin. There are also several studies underway that suggest ergothioneine may be effective as a natural preservative.
 

How do you extract ergothioneine?

Hot-water extraction with optimal conditions-125 rpm at 75°C for 5 minutes-produced P. eryngii and P. citrinopileatus extracts with 0.86 and 3.73 mg ergothioneine/g dry weight, respectively

FAQ

1. What's the MOQ?

No limit for MOQ. It ups the customers' demand.

2. How long is lead time?

Usually small quantity are in stock. Large quantity is delivered within one week.

3. How to store ergothioneine?

Usually -20℃

References:

1. Chemical book  www.chemicalbook.com

2. Webmd  www.webmd.com

3. http://en.m.wikipedia.org

4. https://www.futurelearn.com

5. https://pubmed.ncbi.nlm.nih.gov ›

6. https://thenakedchemist.com ›